DelveInsight Highlights Major Advances, Transformative Therapies, and 20+ Leading Players Wheeling the Advanced Merkel Cell Carcinoma Clinical Trial Pipeline Landscape
The Advanced Merkel Cell Carcinoma Pipeline Insight 2023 report by DelveInsight offers a thorough global overview of Advanced Merkel Cell Carcinoma treatments, including those already in the market, as well as those in different phases of clinical development. Prominent pharmaceutical firms are dedicated to progressing the Advanced Merkel Cell Carcinoma pipeline landscape and fostering the potential growth of Advanced Merkel Cell Carcinoma therapeutic advancements.
Key Takeaways from the Advanced Merkel Cell Carcinoma Pipeline Report
- DelveInsight’s Advanced Merkel Cell Carcinoma pipeline report depicts a robust space with 20+ active players working to develop 20+ pipeline therapies for Advanced Merkel Cell Carcinoma treatment.
- The leading companies working in the Advanced Merkel Cell Carcinoma market include Xencor Inc., Incyte Corporation, Millennium Pharmaceuticals, Inc., Exelixis, Bristol-Myers Squibb, bluebird bio, Affini-T Therapeutics, ImaginAb, Inc., BioInvent International AB, Ocellaris Pharma, Inc., Sotio a.s., Morphogenesis Inc., Checkpoint Therapeutics, Inc., and others.
- Promising Advanced Merkel Cell Carcinoma Pipeline Therapies in the various stages of development include Pembrolizumab (MK-3475), Avelumab, Cemiplimab-Rwlc, FF-10850 Topotecan Liposome Injection, IFx-Hu2.0, Vidutolimod, Cemiplimab, INCB099318, SO-C101, CK-301 (cosibelimab), and others.
- On February 2023, Merck Sharp & Dohme LLC announced a study of Phase 3 Clinical Trials for Pembrolizumab (MK-3475). This is a single-arm, open-label, multicenter, efficacy, and safety study of pembrolizumab in adult and pediatric participants with previously untreated advanced Merkel Cell Carcinoma (MCC). The primary objective of the trial is to assess the objective response rate, as assessed by blinded independent central review per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) modified to follow a maximum of 10 target lesions and a maximum of 5 target lesions per organ, following administration of pembrolizumab.
- On June 2023, Memorial Sloan Kettering Cancer Center announced a study of Phase 2 Clinical Trials for Avelumab. This study will test the use of comprehensive ablative radiation therapy (CART), with the immunotherapy drug avelumab, in people with Merkel cell carcinoma (MCC) that has progressed after treatment and cannot be removed with surgery. The study researchers want to find out if CART works well when combined with avelumab.
- On July 2023, 4SC AG announced a study of Phase 2 Clinical Trials for Domatinostat in Combination with Avelumab. This phase II trial studies how well domatinostat (4SC-202) works in combination with avelumab in adult patients with advanced unresectable and/or metastatic Merkel Cell Carcinoma that have progressed on a previous therapy with an anti-PD-(L)1 antibody.
- On August 2023, H. Lee Moffitt Cancer Center and Research Institute announced a study of Phase 1 Clinical Trials for Cemiplimab-Rwlc. The goal of this clinical research study is to determine if Cemiplimab-rwlc (called Cemiplimab in this document) given prior to tumor resection surgery is safe and effective in treating (1) Merkel Cell Carcinoma or (2) Cutaneous Squamous Cell Carcinoma (CSCC).
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The Advanced Merkel Cell Carcinoma pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage Advanced Merkel Cell Carcinoma drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the Advanced Merkel Cell Carcinoma clinical trial landscape.
Advanced Merkel Cell Carcinoma Overview
Advanced Merkel cell carcinoma (MCC) is a very aggressive, rare neuroendocrine tumor of the skin with a high frequency of locoregional recurrence and metastasis, and a high mortality rate. Surgical resection, sentinel lymph node biopsy, and radiotherapy represent the gold standard of treatment in patients with localized disease, while chemotherapy has a significant role in the treatment of advanced disease.
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Advanced Merkel Cell Carcinoma Emerging Drugs Profile
- Tidutamab: Xencor, Inc.
- Cabozantinib: Exelixis
Advanced Merkel Cell Carcinoma Pipeline Therapeutics Assessment
There are approx. 20+ key companies which are developing the therapies for Advanced Merkel cell carcinoma. The Advanced Merkel Cell Carcinoma companies which have their Advanced Merkel cell carcinoma drug candidates in the most advanced stage, i.e. phase II include, Exelixis.
Learn more about the emerging Advanced Merkel Cell Carcinoma Pipeline Therapies @ Advanced Merkel Cell Carcinoma Clinical Trials Assessment
Scope of the Advanced Merkel Cell Carcinoma Pipeline Report
- Coverage- Global
- Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
- Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
- Advanced Merkel Cell Carcinoma Companies- Xencor Inc., Incyte Corporation, Millennium Pharmaceuticals, Inc., Exelixis, Bristol-Myers Squibb, bluebird bio, Affini-T Therapeutics, ImaginAb, Inc., BioInvent International AB, Ocellaris Pharma, Inc., Sotio a.s., Morphogenesis Inc., Checkpoint Therapeutics, Inc., and others.
- Advanced Merkel Cell Carcinoma Pipeline Therapies- Pembrolizumab (MK-3475), Avelumab, Cemiplimab-Rwlc, FF-10850 Topotecan Liposome Injection, IFx-Hu2.0, Vidutolimod, Cemiplimab, INCB099318, SO-C101, CK-301 (cosibelimab), and others.
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Table of Content
- Introduction
- Executive Summary
- Advanced Merkel cell carcinoma: Overview
- Pipeline Therapeutics
- Therapeutic Assessment
- Advanced Merkel cell carcinoma – DelveInsight’s Analytical Perspective
- Mid Stage Products (Phase II)
- Cabozantinib: Exelixis
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- IFx-Hu2.0: Morphogenesis
- Drug profiles in the detailed report…..
- Inactive Products
- Advanced Merkel cell carcinoma Key Companies
- Advanced Merkel cell carcinoma Key Products
- Advanced Merkel cell carcinoma- Unmet Needs
- Advanced Merkel cell carcinoma- Market Drivers and Barriers
- Advanced Merkel cell carcinoma- Future Perspectives and Conclusion
- Advanced Merkel cell carcinoma Analyst Views
- Advanced Merkel cell carcinoma Key Companies
- Appendix
For further information on the Advanced Merkel Cell Carcinoma pipeline therapeutics, reach out to Advanced Merkel Cell Carcinoma Unmet Needs and Analyst Views
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